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5 x 22LB R-454B Freon Refrigerant Gas cylinders on a wooden pallet, ideal for modern low-GWP HVAC systems
3D rendered front view of 22lb R454B refrigerant cylinder, flammable gas for modern high-efficiency HVAC and low-GWP refrigeration systems
3D rendered side view of 22lb R454B refrigerant cylinder with safety warning labels for modern high-efficiency HVAC systems
3D rendered side view of 22lb R454B refrigerant cylinder with liquid/vapor usage instructions for modern high-efficiency HVAC systems
3D rendered overhead view of 22lb R454B refrigerant cylinder top valve assembly for modern high-efficiency HVAC systems
3D rendering close-up top view of a 22 lb R454B refrigerant cylinder valve (with safety handle) for modern, high-efficiency HVAC systems
3D rendered front view of 22lb R454B refrigerant cylinder and packaging with UN 3161 flammable gas label for modern high-efficiency HVAC systems
5 x 22LB R-454B Freon Refrigerant Gas cylinders on a wooden pallet, ideal for modern low-GWP HVAC systems
3D rendered front view of 22lb R454B refrigerant cylinder, flammable gas for modern high-efficiency HVAC and low-GWP refrigeration systems
3D rendered side view of 22lb R454B refrigerant cylinder with safety warning labels for modern high-efficiency HVAC systems
3D rendered side view of 22lb R454B refrigerant cylinder with liquid/vapor usage instructions for modern high-efficiency HVAC systems
3D rendered overhead view of 22lb R454B refrigerant cylinder top valve assembly for modern high-efficiency HVAC systems
3D rendering close-up top view of a 22 lb R454B refrigerant cylinder valve (with safety handle) for modern, high-efficiency HVAC systems
3D rendered front view of 22lb R454B refrigerant cylinder and packaging with UN 3161 flammable gas label for modern high-efficiency HVAC systems

22Lb R454B Refrigerant Gas R-454B | (5 Cylinders / 110lb Total)

Sale price $2,945.00
Quantity: 5 Cylinders
1 Cylinders 5 Cylinders 10 Cylinders 20 Cylinders 40 Cylinders
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ETA: Goods are expected to be received between and
  • Next-Generation Refrigerant
    Developed as a lower-GWP alternative to R-410A.
  • Improved Environmental Profile
    Helps reduce environmental impact while maintaining performance.
  • Efficient Cooling Performance
    Delivers reliable and energy-efficient operation.
  • Future Compliance Ready
    Supports evolving environmental regulations and system upgrades.
  • Fast & Reliable U.S. Shipping
    Ships within 24 hours from our U.S. warehouse, with 2–4 business day delivery.
Free
Shipping
14 Days
Return
100%
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R-454B is a next-generation refrigerant designed for modern HVAC systems, providing high energy efficiency with significantly lower environmental impact compared to traditional blends like R-410A.

Key Features:
  • Ultra-low Global Warming Potential (GWP 466)
  • Excellent system performance with comparable capacity and efficiency to R-410A
  • Single-component blend designed for safe use in modern low-GWP HVAC systems
  • Widely adopted in new residential, commercial, and industrial HVAC equipment
Physical Properties:
  • Chemical Composition: R-32 (68.9%), R-1234yf (31.1%)
  • Molecular Formula: Blend
  • Boiling Point: -54.4°C (-65.9°F)
  • GWP: 466
  • ODP: 0
  • ASHRAE Safety Classification: A2L (Mildly Flammable, Non-Toxic)
Applications:
  • Residential and light commercial HVAC systems
  • Commercial heat pumps
  • VRF systems and chillers
Packaging:
  • Net Weight: 22lb (10kg) per cylinder
  • Cylinder Type: Steel bottle, disposable
  • Storage: Store upright in a cool, dry, ventilated area. Avoid direct sunlight and high temperatures. Follow local handling regulations.
Shipping and Safety:
  • Complies with applicable hazardous materials regulations for transport.
  • Handle using appropriate safety equipment and follow local safety codes.

 

R-454B Physical Properties
Chemical Composition R-32 (68.9%), R-1234yf (31.1%)
Boiling Point -54.4°C (-65.9°F)
GWP (Global Warming Potential) 466
ODP (Ozone Depletion Potential) 0
ASHRAE Safety Class A2L
Packaging Net Weight: 22lb 
Cylinder Type Disposable steel tank
Storage Store in upright position, away from flames and direct sunlight. Max temp: 52°C (125°F)

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5 x 22LB R-454B Freon Refrigerant Gas cylinders on a wooden pallet, ideal for modern low-GWP HVAC systems

22Lb R454B Refrigerant Gas R-454B | (5 Cylinders / 110lb Total)

$2,945.00

✔ EPA Section 608/609

All refrigerant sales comply with EPA Section 608 or 609 regulations, depending on the application.

✔ SDS Available

Safety Data Sheets are provided for every product, covering handling, storage, and safety information.

✔ DOT-Compliant Shipping via FedEx

All shipments comply with U.S. DOT hazardous materials regulations and are delivered via trusted carriers like FedEx.

Refrigerant Lab 454B(R-454B) Refrigerant

Two HVAC technicians in safety gear inspect an outdoor air conditioning and ventilation system. One holds a tablet, likely reviewing system data or schematics, while the other stands on a ladder, preparing to service the ductwork and AC units mounted on the building exterior.

A next-generation low-GWP refrigerant
for sustainable HVAC applications

Widely used in:

  • Residential and light commercial air conditioning
  • Heat pump systems
  • New HVAC equipment designed for low-GWP refrigerants
  • Applications transitioning from R-410A

R-454B is a next-generation refrigerant blend developed as an environmentally responsible
alternative to R-410A. It features significantly lower global warming potential (GWP), zero
ozone depletion potential (ODP = 0), and strong energy efficiency. With similar operating
characteristics to R-410A, R-454B enables a smoother transition for modern HVAC systems
while supporting sustainability goals and regulatory compliance. Its balanced performance
and reduced environmental impact make it a reliable choice for next-generation
air conditioning and heat pump applications.

Why Choose Refrigerant Lab

We support bulk supply, private labeling, and long-term procurement for qualified partners.

Our manufacturing model allows flexible coordination for commercial and OEM refrigerant requirements.

Industrial manufacturing facility for refrigerant production and HVAC component assembly

1. Direct Manufacturer with In-House Production

Refrigerant Lab operates with dedicated manufacturing facilities, enabling full control over refrigerant formulation, filling, and quality management—without reliance on third-party repackaging.

Modern stainless steel tanks used for storing high-purity refrigerant products in a production facility

2. Consistent Virgin-Grade Quality Control

All refrigerants are produced using virgin-grade raw materials and follow controlled manufacturing processes.
Each batch undergoes internal inspection to ensure compliance with industry purity standards.

Executives finalizing a commercial agreement for eco-friendly refrigerant products

3. Compliance Built into Manufacturing

Regulatory compliance is integrated throughout our production process.
From manufacturing to packaging, our refrigerants are handled in accordance with applicable U.S. EPA regulations and industry requirements.

Logistics team loading eco-friendly refrigerant supplies into a truck for timely HVAC industry delivery

4. Certified Filling & Secure Cylinder Handling

Our in-house facilities utilize standardized cylinder filling and sealing procedures, ensuring safe containment and compliance with hazardous materials transportation regulations.

Bulk supply of eco-friendly refrigerants (R404A, R407C) ready for shipment to HVAC and cooling applications

5. Reliable Supply Backed by Production Capacity

As a manufacturer, we maintain stable production capacity and inventory planning, allowing us to support ongoing demand from HVAC professionals and commercial customers without supply disruption.

Refrigerant Product FAQ

1. Is this refrigerant compliant with U.S. regulations?

Yes. This refrigerant is supplied in accordance with applicable U.S. EPA regulations for refrigerant distribution and handling.

We accept major payment methods including Visa, MasterCard, American Express, Discover, Diners Club, Apple Pay, Google Pay, PayPal, and Shopify Pay. All payments are securely processed through Shopify’s trusted payment system.

Orders are typically dispatched within 24 hours from our U.S. warehouse and delivered within 2–4 business days via trusted carriers such as FedEx. All shipments are securely packaged and transported in accordance with U.S. DOT hazardous materials regulations, ensuring safe handling and compliance throughout the delivery process.

Yes — technical and safety documentation is available for each product model on our website.

Yes. Commercial and bulk purchasing options are available for qualified customers.
Please contact us for additional information.